Bliss 5-Pack

SAMe is the “universal” methyl donor for biochemical reactions
throughout the body. This methyl transfer, or “transmethylation,” is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of cell membranes, degradation of histamine, and formation of norepinephrine and dopamine. Eighty-five percent of transmethylation takes place in the liver, and healthy SAMe levels appear to be essential to liver health and function.

Bliss' SAM-e contains a minimum of 70% of the SS isomer of SAMe, the form the body can use most readily. This relatively high concentration from Gnosis’ Adomix® not only makes SAM-e particularly bioavailable but also cost-effective. Each capsule is sealed in a nitrogen-purged blister pack to maximize protection from the environment.

SAMe is considered to be “critical” for synthesis of glutathione, a principal component of antioxidant and detoxification systems in the body. Following donation of a methyl group, SAMe is converted to S-adenosylhomocysteine (SAH). This biochemical reaction promotes the transsulfuration pathway in the liver that generates glutathione. Further metabolism of SAH involves trimethylglycine (TMG), also known as betaine anhydrous. TMG plays an important role in maintaining a healthy SAMe:SAH ratio in the liver.

Trimethylglycine is a naturally occurring compound (glycine attached to three methyl groups) that is found in naturally and can be produced in the body from the precursor choline. TMG is thought to protect liver cells, support homocysteine metabolism and cardiovascular health, and may also support a healthy mood due to its role in SAMe metabolism. When TMG donates a single methyl group, it is converted to dimethylglycine (DMG), which is capable of donating two methyl groups. TMG is thought to stimulate activity of the enzyme betaine-homocysteine methyltransferase (BHMT). BHMT, found in abundance in a healthy liver, is used by TMG to donate a methyl group to homocysteine. Once TMG adds a methyl group to homocysteine to produce methionine, the methionine can then be converted to SAMe. A randomized, double-blind, crossover study of healthy volunteers suggested that TMG supplementation (at doses of 3 g and 6 g/d) has a dose-dependent effect on serum TMG levels and a significantly positive effect on maintaining healthy homocysteine levels. together, SAMe and TMG provide an abundant source of methyl groups and ultimately support a wide variety of biochemical reactions in the body.